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#5921: LDL (Low Density Lipoprotein) Subfractions 5/21/2013
Components
  Name Method Reference Range Units
LDL 1 EP  < 58   mg/dL  
LDL 2 EP  < 31   mg/dL  
LDL 3 EP  < 7   mg/dL  
LDL 4 EP  < 1   mg/dL  
LDL 5 EP  < 1   mg/dL  
LDL 6 EP  < 1   mg/dL  
LDL 7 EP  < 1   mg/dL  
Cholesterol, Total S  < 20 years: 125 - 170
>= 20 years: 125 - 200  		 mg/dL  
Calculated LDL CALC  < 130   mg/dL  
Mean LDL Particle Size CALC  > 26.7   nm  

Specimen Requirements
  Type Volume Temperature Instructions
PRIMARY
1 Serum Fasting 12 hr 2 (1) mL2 (1) mL   Refrigerated - 7 Day(s)
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Split into two 1mL aliquots before shipping.///
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Clinical Utilities
The measurement of LDL subfractions can be used to identify individuals at increased risk for coronary artery disease (CAD) and atherosclerosis. Small dense LDL particles (Non-type A) are more atherogenic than large LDL particles. The density of LDL particles is related to the triglyceride content, and may be more readily oxidized, or could be a marker for delayed clearance of atherogenic remnant particles. Non-Type A profiles may be found in individuals with borderline or elevated total cholesterol levels. The prevalence of Non-Type A increases with age, Type 2 diabetes, obesity, and post menopause. LDL particle size is valuable in predicting patient response to specific therapies to reduce CAD progression.

Setup Schedule
Tuesday, Friday

Reported (Analytical Time)
Same day

CPT Codes
82465, 83701

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Frozen specimens are unacceptable. Please include fasting status on requisition.