The measurement of LDL subfractions can be used to identify individuals at increased risk for coronary artery disease (CAD) and atherosclerosis. Small dense LDL particles (Non-type A) are more atherogenic than large LDL particles. The density of LDL particles is related to the triglyceride content, and may be more readily oxidized, or could be a marker for delayed clearance of atherogenic remnant particles. Non-Type A profiles may be found in individuals with borderline or elevated total cholesterol levels. The prevalence of Non-Type A increases with age, Type 2 diabetes, obesity, and post menopause. LDL particle size is valuable in predicting patient response to specific therapies to reduce CAD progression.
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
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Frozen specimens are unacceptable. Please include fasting status on requisition.