C-ANCA are present in 70-90% of patients with generalized Wegener granulomatosis (WG). C-ANCA-postive sera containing PR-3 Ab are 80% sensitive and 97% specific for WG. Positive ANCA results obtained in patients with other types of vasculitis typically give a P-ANCA pattern and are usually associated with autoantibodies to myeloperoxidase. Autoantibodies to bactericidal permeablility increasing protein (BPI) are found in about 91% of cystic fibrosis patients, 28% of ulcerative colitis, 22% of Crohn disease, 20% of primary biliary cirrhosis, 18% of primary sclerosing cholangitis and 5% of Henoch-Schoenlein purpura.
Reported (Analytical Time)
83520, 86021x3, 86039
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If result for ANCA Total Autoantibodies is 1:20 or greater, ANCA IgG, IgM and IgA Autoantibodies test code #1022 may be requested as an "Add-on" test. BPI IgG Autoabs: This test(s) was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics Nichols Institute, Valencia, CA. This test should not be used for diagnosis without confirmation by other medically established means.