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16029: ABL Kinase Domain Mutation in CML, Cell-based Print View
ABL Mutation, Cell-based      
ABL Possible Mutations      

PRIMARY
1 Bone Marrow EDTA 2.1 (1) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
ALTERNATE
  Whole Blood Heparin 6 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Bone Marrow Heparinized   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Bone Marrow ACD Sol B   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
  Whole Blood ACD Sol B 6 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Whole Blood EDTA 6 (4) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  

Imatinib mesylate (ST1571;Gleevec) is a selective BCR-ABL kinase inhibitor, effective in the treatment of chronic myelogenous leukemia (CML). Most patients in chronic phase maintain durable responses; however, many in blast crisis fail to respond, or relapse quickly. ABL kinase domain mutations are the most commonly identified mechanism associated with relapse. The molecular monitoring in the first few months of therapy may play a crucial role in detecting patients at high risk of Imatinib resistance. This ABL kinase mutation assay may detect drug-resistant mutations before clinical relapse and identify candidate suitable for alternative therapy.

Preferred collection containers are EDTA (lavender-top) tube, sodium
heparin (green-top), or ACD solution B (yellow-top) tube.
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
3 days

CPT Code
81170

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Gross hemolysis; lipemia; frozen samples; clotted whole blood samples; clotted bone marrow samples
Transport Temperature: Refrigerated
Methodology: Real-Time Polymerase Chain Reaction, Nested Polymerase Chain Reaction, Sequencing






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