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Specialty
introduces Cartilage Oligomeric Matrix Protein (COMP) --
a new marker for assessing active cartilage destruction
COMP is a glycoprotein component of the articular cartilaginous
matrix. When cartilage matrix is degraded by disease, protein
fragments are produced that diffuse into the joint fluid. These
proteins, including COMP, subsequently appear in the circulation
and can be used to monitor cartilage degradation in inflammatory
joint diseases such asRheumatoid Arthritis (RA) and osteoarthritis.
Specialty 's COMP assays may be useful for:
- Assessing Level of Cartilage Degradation
- High COMP concentrations (>15) indicate severe active cartilage
breakdown1,2
- Prognosis for Continued Erosion
- High COMP concentrations (>15) are a strong predictor of
continued cartilage erosion1,2
Specialty is also pleased to offer Cyclic Citrullinated
Peptide (CCP) IgG Antibody, a highly specific marker for RA
that is detected in 70% of RA patients in the early stages of disease.
Unlike Rheumatoid Factor (RF), CCP is found almost exclusively in
those with RA.3.
For more information, you may refer to the documents on the right
or contact Client Services at 800-421-4449.
References
- Månsson B, Carey D, Alini M, et al. Cartilage and bone
metabolism in rheumatoid arthritis. Differences between rapid
and slow progression of disease identified by serum markers
of cartilage metabolism. J Clin Invest 1995;95:1071-7.
- Skoumal M, Kolarz G, Klingler A. Serum levels of cartilage
oligomeric matrix protein. A predicting factor and a valuable
parameter for disease management in rheumatoid arthritis. Scan
J Rheumatol 2003;32:156-61.
- Kroot EJJA, de Jong BAW, van Leeuwen MA, et al. The prognostic
value of anti-cyclic citrullinated peptide antibody in patients
with recent-onset rheumatoid arthritis. Arthritis Rheum 2000;43:1831-5.
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