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#QC.23042: C1 Inhibitor, Functional

COMPONENTS
Name Method Reference Range Units
C1 Inhibitor, Functional Immunoassay >= 68 % Normal
41-67 % Equivocal
<= 40 % Abnormal
Less than 40% of the reference functional activity indicates a likely diagnosis of hereditary angioedema or acquired C1 inhibitor deficiency.

SPECIMEN REQUIREMENTS
No Type Volume Temperature Container Type Instructions
1 1 mL serum collected in a red-top tube (no gel) Minimum Volume 0.2 mL Frozen red-top tube (no gel Collection Instructions
Freeze serum within 1 hour of time drawn. Do not use gel barrier tubes. Do not submit the sample in a glass tube. Do not thaw.

 

GENERAL INFORMATION
Setup Schedule Tues, Fri p.m
Turn-Around Time Report available: Next day
CPT Code 86161
Performing Lab Quest Diagnostics Nichols Institute, Chantilly, VA
Test Performed Stat No
Clinical Utilities Clinical Significance
C1 esterase is decreased in angioedema. The inherited form is usually diagnosed in the first two decades of life. The acquired form affects primarily adults with autoimmune or lymphoproliferative disorders. Approximately 15% of patients with hereditary angioedema have a normal concentration of the protein but it is dysfunctional.