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#CDTA: Carbohydrate Deficient Transferrin, Adult, Serum (CDT)

COMPONENTS
Name Method Reference Range Units
Carbohydrate Deficient Transferrin Affinity Chromatography/Mass Spectrometry (MS) < or =0.10

0.11-0.12 (indeterminate)


SPECIMEN REQUIREMENTS
No Type Volume Temperature Container Type Instructions
1 Serum 0.1 Refrigerated Red-Top Tube  

GENERAL INFORMATION
Setup Schedule Wednesday
Turn-Around Time 5 days
CPT Code 82373
Notes Note:
1. This test is for evaluation of alcohol abuse.
2. Patient's Age is required for processing
3. Reason for referral is required if patient is <21 years old.
Performing Lab Mayo Medical Laboratory, Rochester
Test Performed Stat No
Clinical Utilities Chronic alcoholism causes a transient change in the glycosylation pattern of transferrin where the relative amounts of disialo- and asialotransferrin (carbohydrate deficient transferrin [CDT]) are increased over the amount of normally glycosylated tetrasialotransferrin. This recognition led to the use of CDT in serum as marker for chronic alcohol abuse. CDT typically normalizes within several weeks of abstinence of alcohol use. However, it is important to recognize that there are other causes of abnormal CDT levels, which include congenital disorders of glycosylation (CDG) and other genetic and non-genetic causes of acute or chronic liver disease.

CDT testing alone is not recommended for general screening for alcoholism; however, when combined with other methods (ie, gamma-glutamyltransferase, mean corpuscular volume, patient self-reporting) clinicians can expect to identify 90% or more of heavily drinking patients.