1. This test is for evaluation of alcohol abuse.
2. Patient's Age is required for processing
3. Reason for referral is required if patient is <21 years old.
||Mayo Medical Laboratory, Rochester
|Test Performed Stat
Chronic alcoholism causes a transient change in the glycosylation pattern of transferrin where the relative amounts of disialo- and asialotransferrin (carbohydrate deficient transferrin [CDT]) are increased over the amount of normally glycosylated tetrasialotransferrin. This recognition led to the use of CDT in serum as marker for chronic alcohol abuse. CDT typically normalizes within several weeks of abstinence of alcohol use. However, it is important to recognize that there are other causes of abnormal CDT levels, which include congenital disorders of glycosylation (CDG) and other genetic and non-genetic causes of acute or chronic liver disease.
CDT testing alone is not recommended for general screening for alcoholism; however, when combined with other methods (ie, gamma-glutamyltransferase, mean corpuscular volume, patient self-reporting) clinicians can expect to identify 90% or more of heavily drinking patients.